Motorists on the A15 north of Lincoln were met with traffic chaos on the morning of Monday, January 4 after two Heavy Goods Vehicles (HGVs) collided.
The crash, involving one lorry transporting paint, happened at around 7.40am, outside RAF Scampton.
No serious injuries have been reported.
Police say the road is closed and is likely to remain so for several hours whilst the wreckage of the vehicles and their loads are cleared.
Lincolnshire Highways are setting up diversions, however motorists are being advised to avoid the area.
Anyone who witnessed the collision is asked to call the 101 non-emergency number quoting incident number 47 of January 4.